Biotin
Limited for broad hair and skin claimsDeficiency can affect hair and skin, but deficiency is rare and evidence for high-dose supplements in otherwise healthy people is limited. High doses can interfere with some laboratory tests.
NIH Office of Dietary Supplements source ↗
Collagen peptides
Promising, not settledSome trials report modest changes in skin hydration or elasticity, while formulations, doses and study quality vary. Ingredient evidence is not a finished-product trial.
Harvard Nutrition Source ↗
Vitamin C
Established biological roleVitamin C has established roles in collagen synthesis and antioxidant function. That does not mean extra intake always creates a visible beauty result.
NIH Office of Dietary Supplements source ↗
Zinc
Established nutrient; claim context variesZinc is essential and involved in immune function and wound healing. Long-term high intakes can cause problems including copper deficiency.
NIH Office of Dietary Supplements source ↗
Iron
Individual context mattersTreating a confirmed deficiency matters, but routine iron supplementation is not appropriate for everyone and too much can be harmful.
NIH Office of Dietary Supplements source ↗
Vitamin D
Established nutrient roleVitamin D has established roles in bone, muscle and immune function. Benefit from supplementation depends partly on baseline status and intake.
NIH Office of Dietary Supplements source ↗
Magnesium
Context matters for sleep and stressMagnesium is essential, but research on supplemental magnesium for sleep and stress is mixed and depends on population, form and dose.
NIH Office of Dietary Supplements source ↗
Ashwagandha
Promising, not settledSmall, short studies suggest possible effects on perceived stress or sleep. Preparations vary; long-term safety is uncertain, with pregnancy, liver, thyroid and interaction cautions.
NIH Office of Dietary Supplements source ↗
Probiotics
Strain and outcome specificEffects are strain-, dose- and outcome-specific. A large CFU number alone does not establish that a product supports a particular claim.
NIH Office of Dietary Supplements source ↗
Caffeine
Established effect on alertnessCaffeine can increase alertness and support some exercise outcomes. Individual effects and tolerance vary, so total milligrams per use matter.
European Food Safety Authority source ↗
Creatine
Established performance evidenceCreatine monohydrate has substantial evidence for high-intensity exercise capacity and training adaptations. Form, amount and finished-product quality still matter.
NIH Office of Dietary Supplements source ↗
Retinoid / retinol
Established for specific skin outcomesTopical retinoids have evidence for acne or photo-ageing outcomes. Strength, formulation, irritation risk and product type make a material difference.
American Academy of Dermatology source ↗
Niacinamide
Promising, formulation dependentTopical niacinamide is used for barrier support and appearance-related outcomes. Its position in an ingredient list does not reveal an exact percentage.
DermNet source ↗
Salicylic acid
Established acne-care optionSalicylic acid appears in acne guidelines as a topical option. Concentration, formulation and skin tolerance affect use.
American Academy of Dermatology source ↗
Hyaluronic acid
Promising hydration contextTopical hyaluronic acid mainly acts as a humectant and can support temporary hydration. It is not the same thing as injectable filler.
DermNet moisturiser source ↗
How to interpret this page
The summaries are intentionally narrow and link to the source used by the receipt engine. They are not exhaustive systematic reviews. A library match gives context; a non-match says only that this version of the library does not cover the ingredient.
Last materially reviewed: 26 August 2026. Read the full methodology.